Comment:This mailout lists a number of recent additions to the Cochrane database on IVF topic. Worth a read.
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Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy
Female mice lacking ovastacin did not cleave ZP2 after fertilization, and mouse sperm bound as well to Astl-null two-cell embryos as they did to normal eggs. Ovastacin is a pioneer component of mouse cortical granules and plays a definitive role in t
Cabergoline for preventing ovarian hyperstimulation syndrome
Cabergoline appears to reduce the risk of OHSS in high-risk women, especially for moderate OHSS. The use of cabergoline does not affect the pregnancy outcome (clinical pregnancy rate, miscarriage rate), nor is there an increased risk of adverse event
This review suggests that the administration of amoxycillin and clavulanic acid prior to embryo transfer reduced upper genital tract microbial contamination but did not alter clinical pregnancy rates. The effect of this intervention on live birth is
Surgical treatment for tubal disease in women due to undergo in vitro fertilisation
This review of trials found both laparoscopic salpingectomy and tubal occlusion prior to IVF increase the odds of pregnancy. However, other treatment options still need to be evaluated and the place of restorative tubal surgery in clinical practice n
Embryo freezing for preventing ovarian hyperstimulation syndrome
This updated of the review (D'Angelo 2002) has showed that there is insufficient evidence to support routine cryopreservation and insufficient evidence for the relative merits of intra-venous albumin versus cryopreservation.
Intra-cytoplasmic sperm injection versus conventional techniques for oocyte insemination during in v
IVF gives better fertilisation results than ICSI in couples with male factor subfertility. Pregnancy rates found after IVF and ICSI are comparable for couple with non-male subfertility. If anything, ICSI does not improve on the IVF outcome in these c
Luteal phase support for assisted reproduction cycles
This review showed a significant effect in favour of progesterone for luteal phase support, favouring synthetic progesterone over micronized progesterone. Overall, the addition of other substances such as estrogen or hCG did not seem to improve outco
Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology
The review of trials found evidence that more women will have a pregnancy and baby with blastocyst transfer than with regular IVF. There was however, a higher risk that a women would have fewer embryos to freeze and no embryos available for transfer.
The data from this meta-analysis suggests that acupuncture does increase the live birth rate with in vitro fertilisation (IVF) treatment when performed around the time of embryo transfer. However, this could be attributed to placebo effect and the sm
Immune therapies for women with history of failed implantation undergoing IVF treatment
Implantation is considered to be the bottleneck of the reproductive process (Achache, 2006). Inadequate uterine receptivity is responsible for approximately two-thirds of IVF implantation failures, whereas the embryo itself is thought to be responsib
Key Component in Mother's Egg Critical for Survivial of Newly Formed Embryo
Scientists at A*STAR's Institute of Medical Biology (IMB) discovered that a protein, called TRIM28, normally present in the mother's egg, is essential right after fertilisation[1], to preserve certain chemical modifications or 'epigenetic marks' on a
A survey has revealed many Australians do not know what age their fertility starts to decline.
Researchers from the Fertility Coalition questioned more than 400 men and women and found only 20 per cent of men could name the age when a woman's abil
Ovastacin localized to cortical granules that were exocytosed after fertilization, and recombinant ovastacin cleaved ZP2 when added to zonae pellucidae. Mice lacking ovastacin failed to cleave ZP2 after fertilization, allowing sperm to continue to bi
Seeing Double: 1 in 30 Babies Born in US Is a Twin
Women having children at older ages and the growing availability of fertility treatments has led to a marked increase in the birth of twins: In 2009, one in every 30 babies born in the United States was a twin compared with one in every 53 in 1980.
QAPonline Embryo ranking EQA [This link may be from a sponsor]
A new EQA scheme for embryologists where embryologists are graded on their capacity to rank up to 10 embryos relevant to other participants. All clinical and scientific director should enrol their staff to gauge the uniformity of the skills of their
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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