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Does the meiotic spindle really predicts embryo implantation and live birth rates? An update
Despite the different methodology used in all the chosen studies, presence of the MS in oocytes was found to be positively associated with embryo implantation. Moreover, high retardance values, as well as strict criteria of normality in the MS structure, are significantly related to higher embryo implantation numbers and live birth rates.
Predictive value of spindle retardance in embryo implantation rate
Conclusion: Meiotic spindle imaging may be a valuable tool for prediction of oocyte quality, and retardance values of meiotic spindles, together with classical morphological classification, can be useful to select embryos with a higher implantation potential.
In vitro fertilisation/intracytoplasmic sperm injection beyond 2020
What is undeniable is that there will be a sustained global growth in utilisation of ART and that reproductive tourism will allow many people to access the treatment they desire notwithstanding national regulations that may forbid some approaches. The greatest challenge is to expand access to ART to those living in the less wealthy nations who are equally deserving of its benefits.
Effects of the microfluidic chip technique in sperm selection for intracytoplasmic sperm injection for unexplained infertility: a prospective, randomi
Conclusion: Our study showed that the microfluidic technique does not change fertilization, CPR, and LBR during IVF treatment for couples with unexplained infertility. Despite the fact that the total number of grade 1 embryos after ICSI treatment and the surplus number of grade 1 embryos after embryo transfer were higher in the microfluidic technique group, the study was not powered to detect this difference.
Father loses damages claim over forged IVF signature
Man sought payout from clinic in London after his ex forged his consent for procedure.A father whose ex-partner forged his signature to conceive a daughter has lost a damages action against a London IVF clinic at the court of appeal. The man, who can only be identified as ARB, sued IVF Hammersmith after his ex, R, was impregnated with a frozen egg fertilised by his sperm in October 2010, months after they had separated. He claimed compensation fo
Father whose ex forged his signature on an IVF form loses compensation claim from the clinic after Appeal Court judges rule it is ‘morally unaccepta
A father whose ex partner forged his signature on an IVF form has failed to win compensation from a fertility clinic because his healthy daughter is a blessing to him. The man’s former girlfriend simulated his signature to trick doctors into impregnating her with a frozen egg fertilised by his sperm. The father is now devoted to his seven-year-old daughter, but sued fertility clinic, IVF Hammersmith, for the seven-figure costs of bringing her up.
IVF SHOCK: Fertility clinic in Spain compensates couple after discovering that another man fathered their twins
A FERTILITY clinic must compensate a Bilbao couple with €230,000 after discovering that another man fathered their twin sons. Throughout 2015 the couple underwent IVF fertility treatment and the woman’s eggs were fertilised by the husband’s sperm. The embryos were successfully transferred to the mother who carried and gave birth to the twins in 2016 after a normal pregnancy. A year later a routine blood test revealed “incompatibility” between the
Chinese ‘gene-editing’ scientist raises eyebrows by promoting sperm washing for HIV-positive couples
A baby is delivered on the morning of December 2 in Guangzhou, South China's Guangdong Province, by an HIV-infected mother who undertook PMTCT treatment. PMTCT reduces the risk of infant HIV infection to close to zero. Chinese researcher He Jiankui, who claimed to help create the world's first gene-edited babies, is drawing attention to another controversial practice — sperm washing.
Cautious optimism at the first live birth after womb transplant from deceased donor
The news broke on the 4 December 2018 that clinicians had achieved a successful pregnancy and live birth following a uterus transplant from a deceased donor. This has been heralded worldwide as groundbreaking for uterus transplantation, and gives credence to clinical trials persisting with deceased donation, despite previous attempts failing. The feasibility of the use of deceased donors for uterus transplants was looking uncertain, and so the de
Platelet-Rich Plasma (PRP) for Ovarian Rejuvenation
Elsewhere in this issue of the VOICE we report on the IRB approval of CHR’s PRP study for the purpose of Ovarian Rejuvenation in women with POF/POI. We also in last month’s VOICE noted that PRP has been in clinical use in Europe and in a number of centers in the U.S., though without any published evidence of success.
Video Links / [Posted:22/12/2018] / [Source:www.centerforhumanreprod.com] Viewed: 950
Comments Linked to this Mailout
Title
Does the use of a Sperm Selection tool for ICSI improve embryo quality and pregnancy rates?
Summary
Yes it improves embryo quality and No, it does not improve pregnancy rates
Comment
In this prospective randomised trial, the use of a microchip (Fertile Chip) over swim-up methodology for preparing sperm for ICSI, 61 couples used sperm prepared by the above microchip tool and another 61 couples use sperm prepared by swim-up protocols. The authors were not able to show any difference in the pregnancy rate between the two methods but did show even in this relatively small study group), significantly more good quality embryos and more surplus usable embryos.|The tool has been shown to deliver a sperm sample of low DNA fragmentation that some may argue is similar to the sperm that binds to the zona and effects normal (ie IVF insemination) fertilisation. Sperm with low DNA fragmentation have been shown to be associated with lower miscarriage rates. As such, they represent a pool of sperm preferred for IVF/ICSI.| In effect, sperm with low DNA fragmentation also have good motility and normal morphology as does sperm from swim-up methodology. So it is not surprising that there was no difference in the pregnancy rate. What was interesting was they were able to show better embryo quality.| Using a defined process to restrict the sperm to a defined population using the microchip has some important advantages not the least being a form of standardisation for sperm used in IVFICSI. It is a problematic aspect of current IVF technology especially for ICSI that the sperm selected by the embryologist for the insemination of the oocytes in each cohort is largely unregulated and at the mercy of the scientists own preferences and skills. The clinic to a large extent has little control over what sperm is injected and therefore on many aspects including embryo quality. Using a microchip at least defines the population used for sperm selection to a more homogeneous one. Even though there is a cost to using the chip, one may (and should) argue that the cost is worthwhile if it ensures all the sperm injected at ICSI has the lowest risk of generating an embryo that may miscarriage. Given the choice, it is almost certain the clinics clients would request it and if they miscarry could ask why!|
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In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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