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An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming
We designed an oviduct-on-a-chip platform to better investigate the mechanisms related to (epi)genetic reprogramming and the degree to which they differ between in vitro and in vivo embryos. The device supports more physiological (in vivo-like) zygote genetic reprogramming than conventional IVF. This approach will be instrumental in identifying and investigating factors critical to fertilization and pre-implantation development, which could impro
Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles
We then compared transcriptome profiles of aneuploid embryos to those of normal embryos. We observed that non-viable embryos had a large number of dysregulated genes, some showing a hundred-fold difference in expression. On the contrary, sex chromosome abnormalities, XO and XXX displayed transcriptomes more closely mimicking those embryos with 23 normal chromosome pairs. Intriguingly, we identified a set of commonly deregulated genes in the major
Single best euploid versus single best unknown-ploidy blastocyst frozen embryo transfers: a randomized controlled trial
Conclusion: In young (≤:35 years) infertile patients with at least two ≥:2BB blastocysts, PGT-A blastocyst selection does not result in an enhanced LB rate, with the evidence suggesting that the effectivity of PGT-A may be limited by the effectivity of TE biopsy.
A successful healthy childbirth and an ongoing evolutive pregnancy in a case of partial globozoospermia by hyaluronic acid sperm selection
A healthy childbirth and an ongoing evolutive pregnancy in two consecutive ICSI attempts of the same couple suggest that HA sperm selection might assist in cases with partial globozoospermia.
[SPERM SELECTION TECHNIQUES: VISUAL ASSESSMENT VERSUS THE BINDING POTENTIAL TO HYALURONIC ACID].
RESULTS.Thirty couples were randomized to the PVP group and 24 to the slow sperm group: 353 oocytes were injected. There was no statistical difference in fertilization or cleavage rate. Furthermore, in the PVP group, the mean number of embryos was higher and the average morphology of the best embryo was superior.CONCLUSIONS Considering that the HA-based sperm selection technique is more expensive and time consuming, the current study does not sup
Extracellular microRNAs profile in human follicular fluid and IVF outcomes
After adjusting for confounders as BMI, smoking and total motile sperm, associations of these EV-miRNAs remained significant. In-silico KEGG pathway analyses assigned the identified EV-miRNAs to pathways of follicular growth and development, cellular signaling, oocyte meiosis, and ovarian function. Our findings suggest that EV-miRNAs may play a role in pathways of ovarian function and follicle development, which could be essential for understandi
Comparison of DNA fragmentation levels in spermatozoa with different sex chromosome complements
Conclusions: Our results indicated that Y chromosome-bearing spermatozoa are more susceptible to DNA damage than X chromosome-bearing spermatozoa, and the segregation errors during the meiotic division of spermatogenesis (resulting in aneuploidy) constitute an important contributory cause of DNA damage.
Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
These findings highlight a critical role for excess prenatal AMH exposure and subsequent aberrant GnRH receptor signaling in the neuroendocrine dysfunctions of PCOS, while offering a new potential therapeutic avenue to treat the condition during adulthood.
MAGAZINE ‘Sophisticated Labs and High-End Technology Ensure IVF Success Rate’
Out of over a billion people in India almost 4.2 percent suffer from infertility, creating a huge opportunity in the IVF sector. Affordability, awareness, and self regulation are important areas which need to be worked upon to streamline the sector, says Dr Abha Majumdar, Director and Head of IVF, Sir Ganga Ram Hospital, in conversation with Elets News Network (ENN).
Fall in fertility rates spurs in vitro fertilisation market in UAE
In almost 50 per cent of the cases, male infertility is the reason for couples to seek fertility treatment. Fertility rates in the UAE have fallen by 160 per cent from 1960 to 2017, while the demand for in vitro fertilisation (IVF) has gone up considerably, according to a new report. In almost 50 per cent of the cases, male infertility is the reason for couples to seek fertility treatment.
Increased literacy rates and increase in female labour
Does PGT-A improve the pregnancy rate after the transfer of frozen blastocysts.
Summary
In a paired trial, PGT-A embryo assessment did not improve the pregnancy rate of blastocyst FET.
Comment
In a interesting study involving freeze-all cycles from a well respected IVF clinic in Turkey, the group showed that choosing the best frozen blastocysts for transfer based on their morphology but from either a group that were PGT-A tested and confirmed to be euploidy or from a group that were not tested, the live birth rate was the same. In other words, performing PGT-A testing of blastocysts prior to cryopreservation did not increase the likelihood of a live birth.|The authors suggest that any benefit to be derived from the genetic testing may be offset by the efficacy of the testing. In their programme 80/109 blastocysts were found to be normal so in effect some 75% of the untested embryos may expected to also be normal. The flaw in the study was that the clinic transferred up to 2 embryos therefore the likelihood of at least on normal embryo must be very high making any chance of a significant improvement by PGT-A testing unlikely. However comparing the transfer of single highest ranking (by morphological score) blastocysts in a Randomized Controlled Trial (RCT), no statistical difference in LB rate between the euploid subgroup and morphology group (56.3% versus 58.6%, Odds Ratio 0.91 (95% CI (0.51-1.63), p = 0.750) was found.|The study however reflects what often happens at the coal face of IVF - that when the best morphology embryos are transferred, most are highly likely to be euploidy and therefore testing with its cost and handling will not enhance the outcome. Testing on the lesser quality embryos makes more sense and if applied to them may well start to demonstrate improvements.| The other piece of information from this study is that even with 2 good quality, PGT-A tested embryos the live birth rate in a controlled FET environment on clients with the best prognosis (<35 years) was still only 56%. Whilst somewhat better than the very early days of 5-8% per transfer and despite all the latest technology and advances, only 1 in 2 cycles leads to a live birth. Whether this is due to unspecified defects in the culture system, in the process of transfer or finicky endometrium remains unknown surely it is time that clinics started to address this conundrum.|
Title
Extracellular MicroRNAs in Human Follicular Fluid
Summary
Extracellular MicroRNAs Profile In Human Follicular Fluid And IVF Outcomes
Comment
The authors note that " Bidirectional cross-talk between the oocyte and the granulosa cells that line the ovarian follicle is necessary for oocyte competence, fertilization, and ultimately embryo development". They cite previous reports that suggest that "extracellular vehicles (EVs), which include exosomes, macrovesicles and other similar membrane-bound vesicles, can be up-taken in vivo and in vitro by follicular cells, suggesting a possible signaling role within the ovarian follicle.". |
These EV-encapsulated miRNAs (EV-miRNAs) make up a subset of total extracellular RNA. EV-miRNAs are extremely stable and have shown resistance to degradation, compared to free-floating microRNAs, most likely due to their enclosed state and studies have linked EV-mRNA to insulin regulation, epidermal growth factor and transforming growth factor activity.| In this study, the authors looked the range of EV-mRNA in follicles from which oocytes that fertilized and developed to good quality day 3 embryos and compared them to follicles whose oocyte failed to fertilize or failed to develop quality embryos. | From a bank to 192 EV-mRNA, they identified 2 that were overexpressed in immature follicles and 3 whose expression varied from follicles that produced good quality embryos. | Studies such as this paper seeks to use EV-mRNA both as a marked to follicle health and as tool to understand the complex relationship between follicle health and oocyte viability. Given the majority of aneuploidy is a product of oocyte maturation and meiosis, the role of EV-mRNA as a communication pathway between granulosa and cumulus cells is just in its infancy.|
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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