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Novel mutation in the ZP1 gene and clinical implications
Conclusions: Our findings presented compound heterozygous mutations in ZP1 associated with EFS and abnormal oocytes and provided further new evidence for the genetic basis of EFS and support for the genetic diagnosis of infertile individuals.
Elevation of progesterone during the late follicular phase of stimulated in-vitro fertilization cycles is a frequent event, which negatively impacts the outcome. Over the years evidence has demonstrated a direct relationship between late-follicular elevated progesterone and endometrial receptivity. In this regard, elective cryopreservation of all good quality embryos and transfer in a subsequent frozen/thawed cycle is the most common strategy ado
Dual stimulation using corifollitropin alfa in 54 Bologna criteria poor ovarian responders – a case series
Conclusions: Luteal phase stimulation results in more oocytes in poor responders compared with follicular phase stimulation. DuoStim, using corifollitropin alfa followed by individualized FSH dosing, appears to be an alternative to conventional follicular phase stimulation, decreasing the risk of cycle cancellation.
Time-lapse imaging of inner cell mass splitting with monochorionic triamniotic triplets after elective single embryo transfer: a case report
Conclusions: Assisted reproductive techniques and in-vitro culture have been associated with an increased frequency of embryo splitting. This has been postulated to be linked to the in-vitro hatching method observed at the blastocyst stage of development. This case report highlights the need to objectively assess any splitting of the ICM, beyond standard grading of the quality of the ICM and the trophectoderm. Such assessments of ICM splitting sh
Molecular Support for Heterogonesis Resulting in Sesquizygotic Twinning
Sesquizygotic multiple pregnancy is an exceptional intermediate between monozygotic and dizygotic twinning. We report a monochorionic twin pregnancy with fetal sex discordance. Genotyping of amniotic fluid from each sac showed that the twins were maternally identical but chimerically shared 78% of their paternal genome, which makes them genetically in between monozygotic and dizygotic: they are sesquizygotic
Preimplantation genetic testing for aneuploidy (PGT A) The biology, the technology and the clinical outcomes
Preimplantation genetic testing for aneuploidy (PGT A) seeks to identify preimplantation embryos with a normal chromosome complement (euploid) during in vitro fertilisation (IVF). By sifting out embryos with abnormal chromosome numbers (aneuploid), PGT A should theoretically improve pregnancy success.
'Extremely rare' twins born in Brisbane in second reported case in the world
Every parent thinks their child is special, but a Queensland brother and sister truly are unique. They have been identified as the second reported case of semi-identical, or sesquizygotic, twins in the world, and were the first to be diagnosed while still in the womb.It is believed the siblings are the result of one egg being fertilised simultaneously by two sperm
Autologous endometrial cell co-culture improves human embryo development to high-quality blastocysts: a randomized controlled trial
Results: The data demonstrated that AECC significantly increased the incidence of good-quality blastocysts compared with culture in conventional media (42.6% vs 28.4%, P < 0.001). No significant differences were found in pregnancy and live birth rates.
Recent evidence suggests that elective cryopreservation might not entirely resolve the reduced pregnancy outcomes associated with the elevation of progesterone, considering that the increase may affec
Comment
Drakopoulos P, Racca A, Errázuriz J, De Vos M, Tournaye H, Blockeel C, Pluchino N, Santos-Ribeiro S. (2019) The role of progesterone elevation in IVF. Reprod Biol. 2019 Feb 15. pii: S1642-431X(18)30435-2. doi: 10.1016/j.repbio.2019.02.003. [Epub ahead of print] Review. ABSTRACT:Elevation of progesterone during the late follicular phase of stimulated in-vitro fertilization cycles is a frequent event, which negatively impacts the outcome. Over the years evidence has demonstrated a direct relationship between late-follicular elevated progesterone and endometrial receptivity. In this regard, elective cryopreservation of all good quality embryos and transfer in a subsequent frozen/thawed cycle is the most common strategy adopted by clinicians in case of elevated progesterone. Nonetheless, recent evidence suggests that elective cryopreservation might not entirely resolve the reduced pregnancy outcomes associated with the elevation of progesterone, considering that the increase may affect not only implantation, but also embryo quality.
Title
Preimplantation genetic testing for aneuploidy (PGT A)
Summary
Attached is the abstract of Homers article on PGT-A in Aust N Z J Obstet Gynaecol. 2019 Feb 27.
Comment
Abstract|
Preimplantation genetic testing for aneuploidy (PGT A) seeks to identify preimplantation embryos with a normal chromosome complement (euploid) during in vitro fertilisation (IVF). By sifting out embryos with abnormal chromosome numbers (aneuploid), PGT A should theoretically improve pregnancy success. However, earlier versions of PGT A were ineffective, and in some cases, detrimental, due to biopsy induced trauma and because the technology at the time could analyse only a fraction of all chromosomes. More recently, the emergence of technologies enabling all chromosomes to be analysed and a switch to less traumatic blastocyst stage biopsy have seen widespread uptake of PGT A. Assessing the full impact of blastocyst biopsy PGT A requires consideration of multiple factors, including embryonic mosaicism, sensitivity of the technological platform used, embryo loss during long term in vitro culture, embryo cryopreservation and interclinic variability in expertise. Significantly, there hasnt yet been an appropriately designed randomised controlled trial (RCT) of blastocyst biopsy PGT A analysed by intention to treat that accounts for all these parameters on a per cycle basis. The three RCTs reporting benefits studied outcomes on a per embryo transfer basis were small and underpowered and demonstrated benefits for a very select subgroup of good prognosis patients. The liberal use of this very expensive IVF addon for other patient populations has not yet been shown to be effective, or indeed, without harm.|
IVF Training - Questions relating to mailout links -
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Question
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Monochorionic triamniotic triplets means there was only one choronic membrane
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Which of the following may be true about Monochorionic triamniotic triplets.
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IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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Irvine Scientific
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