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Temperature gradients in vivo influence maturing male and female gametes in mammals: evidence from the cow [Bovine]
Temperature gradients are interpreted primarily in a context of final maturation of gametes immediately before the onset of fertilisation. Preovulatory follicular temperature in women could be assessed by a comparable approach and might become a valuable selection guide for oocyte viability.
Impact of diet and bariatric surgery on anti-Müllerian hormone levels
Obese young women might choose bariatric surgery also for fertility reasons, and the observed decrease in FAI is in line with improved fertility. More research is needed to evaluate the clinical effects of the decrease of AMH, and the effect of bariatric surgery prior to IVF treatment.
The prognostic value of perifollicular blood flow in the outcome after assisted reproduction: a systematic review
Results: A total of 14 articles were included in the current review. The results are very heterogeneous, though there is evidence that measuring PFBF could be a good prognostic marker for oocyte and embryo quality, but even more for pregnancy rate after IVF/ICSI. This finding is not observed in studies concerning IUI.
First data on in vitro fertilization and blastocyst formation after intraovarian injection of calcium gluconate-activated autologous platelet rich pla
While autologous PRP has been successfully applied therapeutically to various tissues to accelerate healing and wound repair, this is the first description of direct injection of activated PRP into the human ovary of poor prognosis IVF patients. Evidence of improved ovarian function was noted in all who received intraovarian PRP, possibly as early as two months after treatment.
The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis
WIDER IMPLICATIONS: Although the increased risks of adverse outcome in offspring associated with paternal factors and identified in this report represent serious health effects, the magnitude of these effects seems modest. [Note please read extended summary in article].
Can injection of activated platelet rich plasma [PRP] improve IVF in older women ?
Summary
The injection into the ovaries of women with impaired follicle recruitment with autologous activated platelet-rich plasma appears to improve follicle recruitment, recovery and embryology.
Comment
In a first report by an American clinic, four women, who previously had at least one cancelled cycle due to poor follicle recruitment, had blood collected and a platelet-rich sub-fraction harvested [PRP]. The platelets in this fraction were activated using calcium gluconate and the suspension then returned to the ovaries using a reverse oocyte collection aspiration needle. The suspension was injected into the central body of each ovary with residual injection into the cortical region.// AMH and FSH were monitored as an indication of follicle development over a period of between 59 and 110 days. FSH fell significantly while AMH concentrations rose in a variable manner.// After IVF stimulation and collection, all four clients had 4 or more oocytes recovered, all had blastocysts that were either vitrified (embryo banking) or transferred (x1, pregnant).//The authors explored whether the PRP which contains various angiogenic and cell proliferation growth factors have rescued or connected to growing follicles or whether it encouraged new oocytes (either primoidal or from stem cells) to grow. Regardless, growing follicles do need a healthy vasculature (as another article in this mailout argues).// All clinics are faced with a never ending number of older women and/or those with ovarian failure. Other treatments that include growth hormone or androgen protocols also work to varying degrees. PRP may provide a new and insightful alternative or co-treatment for such clients that is relatively passive and may just, in some cases, provide the additional viable oocytes needed to produce a healthy blastocyst. After all, it only needs one good embryo for pregnancy and one pregnancy changes a clients forever. As the authors note, this concept needs further studies and validation leading to clinical trials but as a number of individual case reports, it seems a interesting first study.//
Title
Can perifollicular blood flow [PFBF] influence embryo quality and pregnancy?
Summary
A review of a limited number of papers on perifollicular blood flow argue that it is associated with better embryo quality and pregnancy.
Comment
The authors have reviewed several aged papers on PFBF based upon small in-house studies, nad found that while follicular blood flow was not associated with oocyte numbers and quality it was associated with improved embryo quality and with pregnancy.// Measuring PFBF is not easy and there have been no reports of it being used dynamically during egg collection because of the difficult logistically issues of using the colour Doppler while trying to aspirate follicles. It is a shame that this area of study has been neglected since vascularisation of follicles is thought to be a key component of early follicle growth and development. One may ask how follicles could continue to grow if they are not vascularised since how else can they gain access to FSH and effect negative feedback if estrogen cannot be adsorbed into the peripheral blood system.// Yet in the age of hyperstimulation, FSH is in such high concentrations that it appears that even in the poorly vascularised region of the ovarian cortex, FSH is available to all follicles regardless of whether they have been able to develop a perifollicular blood flow. As a result, many follicles are induced to grow without a PFBF leading to hypoxic follicles. It is the hypoxic environment that is thought to lead to diminished embryo quality and reduced implantation. It appears that in some cases, women may proceed to egg collection with no or few healthy follicles and little chance of pregnancy.// It seems an opportunity for enterprising clinics may exist to offer enhanced follicle scanning services to include follicle Doppler studies leading to better prognostic advice prior to collection.//
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In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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