There is 1 comment attached to this mailout - Review Comment
If you would like to receive weekly mail digest please Register
OR Forward this mail to a friend
IVFDaily Mail out is about distribution of educational, professional, industry news and product information. If you are a manufacturer or a distributor and wish to make recipients of FertAid Mail aware of your product, please submit a web link here CONTRIBUTE. Listing on IVFdaily.com is Free but inclusion in the mailout attracts a small fee.
From June, 2014 forward, FertAid is developing an online forum for all IVF Clinic Staff. Called IVFClinicMail. When you see this icon against a link, it means there is a comment(s) attached to it. Feel free to click on the icon and contribute.
Jobs
IVFDaily has now provided the tool to advertise any jobs FREE . Simply post the job information as a PDF to office@fertaid.com Listing a position on IVFdaily.com is Free but inclusion in the mailout attracts a small fee.
IVFD
If you receive this distribution by email, then when you click on any link, this linkage will be tagged to your selection list so you can always find it again after you have logged on OR you can click on to mark the link in your file.
Kinetic markers became part of embryo evaluation strategies with the potential to increase the chances of clinical success. However, none of them has been established as an international standard. The present work aims at describing new approaches into time-lapse: progress to date, challenges and possible future directions.
Clinical application of embryo aneuploidy testing by NGS
In conclusion, NGS has become the most appropriate technology for aneuploidy testing in trophectoderm biopsies, with accurate results, high throughput and cost efficiency. This technology can be also applied to the analysis of the embryonic cell free DNA (cfDNA) released to the culture media at blastocyst stage. This is a promising approach towards a non-invasive preimplantation genetic testing of aneuploidy (niPGT-A).
Semen preparation in assisted reproductive technologies (ART) has long been performed using either a simple swim up method or density gradients. Both methodologies provide highly motile sperm populations, however neither replicate the complex selection processes seen in nature. A number of methods have now been developed to mimic some of the natural selection processes that exist in the female reproductive tract. These methods attempt to select a
Cytological and molecular aspects of the ageing sperm
Semen volume, progressive motility and number of progressively motile sperm were significantly lower in elderly than in younger subjects (sextiles 51–81 versus 20–32 years: P < 0.001), while the percentage of abnormal forms in these subjects was significantly higher than in the 20–32 age group (P = 0.002).
This review aims to provide an overview of the current literature surrounding the possibilities of using mitochondria as an additional biomarker for infertility treatment outcome and summarize the reasons as to why there are inconsistencies in these studies.
Ovarian stimulation for preimplantation genetic testing
The aim of ovarian stimulation has shifted from obtaining embryos available for transfer to yielding the maximum embryos available for biopsy to increase the odds of achieving one euploid embryo available for transfer.
Advanced Maternal Age in IVF: Still a Challenge? The Present and the Future of Its Treatment
This review summarizes the main current strategies proposed for the treatment of AMA: (i) oocyte cryopreservation to conduct fertility preservation for medical reasons or “social freezing” for non-medical reasons, (ii) personalized controlled ovarian stimulation to maximize the exploitation of the ovarian reserve in each patient, (iii) enhancement of embryo selection via blastocyst-stage preimplantation genetic testing for aneuploidies and frozen
When your sperm donor becomes part of the family: One couple's IVF success story
In Tasmania, sperm donors are so scarce IVF clinics are flying in supplies from California — a same-sex couple on the waiting list shunned advice against a "known donor" to accept a friend's offer. Now, he is part of the family.
Our genetic inheritance is no longer something given once-and-for-all by fate or God or natural selection. We can now manipulate our genes, reinventing ourselves at the most basic level. So far, curing diseases like Haemophilia has been the aim, but the future is ripe for genetic enhancement.
Business Announcements / [Posted:9/3/2019] / [Source:ourcryptojournal.com] Viewed: 836
Comments Linked to this Mailout
Title
Sperm selection methods in the 21st century
Summary
This reviews covers the latest techniques that may improve the selection of sperm for IVF.
Comment
Denis A Vaughan, Denny Sakkas: Sperm selection methods in the 21st century, Biology of Reproduction, https://doi.org/10.1093/biolre/ioz032|ABSTRACT|
Natural sperm selection in humans is a rigorous process resulting in the highest quality sperm reaching, and having an opportunity to fertilize, the oocyte. Relative to other mammalian species, the human ejaculate consists of a heterogeneous pool of sperm, varying in characteristics such as shape, size and motility. Semen preparation in assisted reproductive technologies (ART) has long been performed using either a simple swim up method or density gradients. Both methodologies provide highly motile sperm populations, however neither replicate the complex selection processes seen in nature. A number of methods have now been developed to mimic some of the natural selection processes that exist in the female reproductive tract. These methods attempt to select a better individual, or population of, spermatozoa when compared to classical methods of preparation. Of the approaches already tested, platforms based upon sperm membrane markers, such as hyaluronan or annexin V, have been used to either select or deselect sperm with varied success. One technology that utilizes the size, motility and other characteristics of sperm to improve both semen analysis and sperm selection is microfluidics. Here, we sought to review the efficacy of both available and emerging techniques, that aim to improve the quality of the sperm pool available for use in ART.|
Title
Does semen quality change with age?
Summary
The bad news is yes, semen quality is significantly related to age and obesity.
Comment
In this report in Human Reproduction from the Semenology lab at the Sapienza’ University of Rome, semen samples of men from between 20 and 81(!) were analysed both cytologically and by molecular analysis.| The authors observed that total sperm count, motility and morphology were inversely related to age. Obesity was inversely related to both motility and morphology.|Smoking did not have effect semen quality after other factors had been removed.|Sperm DNA fragmentation was significantly elevated in older men.|Being aware of the impact of age on semen quality raises the question at to whether a varying normal range based upon age may be worth considering. Older men only rarely have the fertility tested but these results suggest many will fall into the subfertile range. IF the purpose of the test is only to ascertain if IVF or ICSI is warranted then a low sperm count is a low sperm count, regardless of age. If however, the semen analysis is looking at male health then applying a standard range based upon young men may be a unfair to older men.|The study also reinforces the general argument that older men should be discouraged from sperm donation.|
Title
Does Sperm Selection really matter?
Summary
In the quest for minimal miscarriages and healthier children, yes it does matter.
Comment
In this short review of an artilce by Vaughan and Sakkas in Biology of Reproduction, the authors review current and future tools for selecting the optimal spermatozoa for ICSI. They briefly reviewed both the original tools like swim-up and density gradient centrifugation and current tools such as hyaluronic acid (HA) binding tools and finish with a good coverage of future tools that may include microfluidics processes especially when linked to optical enhancement.| So will these tools make a difference? IT depend on where the goal post are set. If increased live births are the end point, then the difference will be small and like HA tools that are expensive and time consuming, will unlikely be incorporated into mainstream IVF protocols. Since there are several other factors the regulate IVF pregnancy rate, most likely sperm selection improvements will never significantly improve the live birth rate.|
However, every story has many perspectives and getting a higher pregnancy rate may not be the most important one. How about minimising the miscarriage rate. Using lower DNA Fragmentation rate as an end point will lead to lower miscarriage rate. Another end point may be may be a healthy young adult that produces healthy children but this will never be know in our lifetime but is probably the best end point of all.|Time-lapse morphokinetics still has some way to go before standardised cleavage set points can be agreed upon as is PGT A. Both may be better end points than live birth.|Another reason to explore and encourage the uptake of sperm selection tools is uniformity in sperm selection. Embryologists performing ICSI are under considerable pressure to complete the injection and selecting a sperm for injection may often be rather rushed and unable to be audited. When taken with sperm samples of aged and poorer quality, its a problem. Using a sperm selection tool, either current or future, will be a good way for IVF senior staff to be assured that all the sperm used to create life meet the highest and most consistent standard. Clients if given the choice of a paying a little bit more for using the very best sperm will almost always request it, even if the live birth rate is unlikely to be better. Maybe the way forward is to separate the selection and the ICSI whereby the Andrology lab prepares small samples of highly selected sperm and cryostores them well before the ICSI. In such cases, there may only need to be one semen sample to be processed saving time and cost during the treatment cycle!|
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
New Developments at FertAid during
July, 2025 and July, 2025
No News
FertAid Functions.
EQA
A range of online Quality Assurance Modules
IVFDaily
New Articles in Press and Interesting, relevant News Items, Business News and other mail
IVFCPD
New education modules
Logbooks
Free Online logbook for IVFLaboratory and Nursing Staff
KPI Benchmarking
New to FertAid. This modules allows ANONYMOUS monthly KPI data entry, management of warning and action limits and anonymous comparisons with country and defined KPI sub-groups
Business
Unlike other mailgroups, IVFDaily will distibute recent business news or developments of interest to IVF staff
to mark the link in your file.
