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No effect of IVF culture medium on cognitive development of 9-year-old children
WIDER IMPLICATIONS OF THE FINDINGS: Our study analyzes the effects of culture medium on school performance of children born after IVF/ICSI in a prospective cohort study. Although further research on long-term academic skills and also on behavior is essential, our results are reassuring and should make parents of children born after IVF/ICSI feel comfortable with their children’s cognitive development.
Associations of blastocyst features, trophectoderm biopsy and other laboratory practice with post-warming behavior and implantation
SUMMARY ANSWER: Blastocyst morphology, day of full development and artificial shrinkage (either laser-assisted or biopsy-induced) are the pre-vitrification parameters/practices most strongly associated with post-warming behavior and implantation potential while there was no association with trophectoderm biopsy.
Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study
SUMMARY ANSWER. Infertile men with severely reduced semen quality risk further deterioration of semen quality 15 years after treatment for infertility, and a lower baseline sperm concentration was associated with a more pronounced increase in LH and decrease in testosterone/LH ratio at follow-up.
'Dr Love' egg-freezing clinic targets young women and single Asians
A Singaporean doctor dubbed "Dr Love" is behind a new egg-freezing clinic in Australia that will target young millenials and prospective single mothers from Asia who can pay per month to keep their eggs on ice. Rising numbers of Australian women are now choosing to freeze their eggs as they wait to meet the right partner.
ObsEva SA reports additional positive Phase 3 results of IMPLANT 2 trial showing significant increase of Live Birth Rate (LBR) following IVF with Sing
In the oral presentation entitled “A Placebo-controlled, Randomized, Double Blind, Phase 3 Study Assessing Ongoing Pregnancy Rates After Single Oral Administration of a Novel Oxytocin Receptor Antagonist, Nolasiban, Prior to Single Embryo Transfer” the primary endpoint results of the IMPLANT 2 trial showed an improvement in the rate of ongoing pregnancy 10 weeks post either Day 3 or Day 5 ET, with nolasiban treatment vs. placebo, 35.6% vs. 28.5%
Does Semen quality from men with spermatogenic failure continue to decrease?
Summary
Spermatogenic failure is associated with severe oligospermia of azoospermia and over time (15 years), the semen quality of such men continued to decrease warranting consideration for cryopreservation.
Comment
In this study from Denmark, men with severe oligospermia (with spermatogenic failure of SgF) were reassessed 15 years after their initial investigations. The teams observations basically showed that a decrease in Leydig cell function as marked by rising LH concentrations was associated with falling sperm concentrations and increased azoospermia. In all 10% of 157 men became azoospemic over this time period.|The recommendations from the authors was that is would be prudent to cryostore semen samples from such men at the initial investigation just in case over future treatment cycles, they became azoospermic and required testicular biopsy.|While some men exhibited an increase in sperm concentration (SC) over, this was only evident when the initial SC was relatively high. In cases with very low SC at the start of the study, almost all decreased significantly over the 15 year interval. A steady testosterone and rising LH is an indication of decreasing leydig cell function. A rising FSH and falling inhibin-B are classic ally associated with falling sperm counts. This study was unable to directly correlate the poorer leydig activity but the associations strongly suggested a distorted function of the seminiferous epithelium.|
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Spermatogenic failure was diagnosed as
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What proportion of men with spermatogenic Failure became azoospermic after 15 years
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Is cryostorage of semen from men with spermatogenic failure recommended?
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Leydig cell dysfunction is indicated by
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In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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