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Association between BMI and semen quality: an observational study of 3966 sperm donors
SUMMARY ANSWER: Underweight was significantly associated with lower sperm concentration, total sperm number and total motile sperm count, while overweight was significantly associated with lower semen volume, total sperm number and total motile sperm count.
Assessment of aneuploidy concordance between clinical trophectoderm biopsy and blastocyst
SUMMARY ANSWER: In the analyzed group of blastocysts, a clinical TE biopsy was an excellent representative of blastocyst karyotype in cases of whole chromosome aneuploidy, but in cases of only segmental (sub-chromosomal) aneuploidy, a TE biopsy was a poor representative of blastocyst karyotype.
Secular trends in semen parameters among men attending a fertility center between 2000 and 2017: Identifying potential predictors
Conclusions: Sperm concentration, total count, motility and morphology significantly declined between 2000 and 2017 among subfertile men. These negative trends were attenuated when considering simultaneous changes in reproductive characteristics and urinary phthalates during the course of the study.
Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles
We observed that non-viable embryos had a large number of dysregulated genes, some showing a hundred-fold difference in expression. On the contrary, sex chromosome abnormalities, XO and XXX displayed transcriptomes more closely mimicking those embryos with 23 normal chromosome pairs - This is the first paper demonstrating a comprehensive transcriptome delineation of karyotypic abnormalities found in the human pre-implantation embryo.
Monozygotic twinning in the IVF era: is it time to change existing concepts?
The initial observations on a series of cases of monozygosity in IVF cycles led authors to suggest a link between the physical condition of the zona pellucida, hatching, and the generation of identical twins [5]. The advent of prolonged culture conditions [6] allowed the evaluation of embryo development and the selection of the “best” embryo for transfer...
Multi-chorionic pregnancies following single embryo transfer at the blastocyst stage: a case series and review of the literature
Conclusion(s): The accepted theory of monozygotic twinning resulting from the splitting of an embryo per a strict post-fertilization timing protocol must be re-examined with the advent of observed multi-chorionic pregnancies resulting from single blastocyst transfer in the context of IVF.
Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations
Whole-chromosome aneuploidy screening has become a common practice to improve outcomes and decrease embryonic transfer order in patients undergoing treatment for infertility through in vitro fertilization. Despite implementation of this powerful technology, a significant percentage of euploid embryos fail to result in successful deliveries. As technology has evolved, detection of subchromosomal imbalances and embryonic mosaicism has become possib
Losing Embryos, Finding Justice: Life, Liberty, and the Pursuit of Personhood
On 3 March 2018, a liquid nitrogen storage tank broke down at University Hospitals Fertility Center in Cleveland, Ohio. More than 950 patients lost over 4000 eggs and embryos (also called “preembryos”) that were frozen and stored for later use. The hospital's letter to patients pointed to human error. The Ohio Department of Health found the fertility center out of compliance, and inquests are still pending (1).
Perspective on legal, ethical implications of lost eggs and embryos
Three medical and legal scholars discussed the implications of one couple's wrongful death suit seeking compensation for the March 2018 loss at a fertility center of more than 4,000 frozen eggs and embryos.
The impact of periconceptional maternal lifestyle on clinical features and biomarkers of placental development and function: a systematic review
The findings revealed that maternal smoking was associated with lower first-trimester placental vascularization flow indices/Alcohol use was associated with a lower placental weight./Adequate nutrition in the first trimester, periconceptional folic acid supplement intake and strong adherence to a Mediterranean diet, were all associated with a lower resistance of the uterine and umbilical arteries in the second and third trimester./
IVF Training - Questions relating to mailout links -
Open Challenge and complete Questions
Question
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Options
First-trimester placental vascularization flow indices with clients who smoked were
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First-Trimester second- and third-trimester resistance of the uterine and umbilical arteriess With Clients Who Smoked Were
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Resistance of the middle cerebral artery With Clients Who Smoked Were
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The impact of smoking on placental weight was expected to be negative but the results from the meta analysis was not clear.
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Alcohol use was associated with a lower placental weight.
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Adequate nutrition in the first trimester, periconceptional folic acid supplement intake and strong adherence to a Mediterranean diet, were all associated with a lower resistance of the uterine and umbilical arteries in the second and third trimester.
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A low caloric intake resulted in a lower placental weight, length, breadth, thickness, area and volume.
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Higher maternal body weight was associated with a larger placenta measured by ultrasound in the second and third trimester of pregnancy or weighed at birth
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IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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