There is 1 comment attached to this mailout - Review Comment
If you would like to receive weekly mail digest please Register
OR Forward this mail to a friend
IVFDaily Mail out is about distribution of educational, professional, industry news and product information. If you are a manufacturer or a distributor and wish to make recipients of FertAid Mail aware of your product, please submit a web link here CONTRIBUTE. Listing on IVFdaily.com is Free but inclusion in the mailout attracts a small fee.
From June, 2014 forward, FertAid is developing an online forum for all IVF Clinic Staff. Called IVFClinicMail. When you see this icon against a link, it means there is a comment(s) attached to it. Feel free to click on the icon and contribute.
Jobs
IVFDaily has now provided the tool to advertise any jobs FREE . Simply post the job information as a PDF to office@fertaid.com Listing a position on IVFdaily.com is Free but inclusion in the mailout attracts a small fee.
IVFD
If you receive this distribution by email, then when you click on any link, this linkage will be tagged to your selection list so you can always find it again after you have logged on OR you can click on to mark the link in your file.
Use of intracytoplasmic sperm injection (ICSI) in normospermic men may result in lower clinical pregnancy and live birth rates
Conclusions: Our data suggest that ICSI may be detrimental to clinical outcomes and contributes to the wider understanding of use of ICSI in normospermic men.
IVF for unexplained subfertility: whom should we treat?
WIDER IMPLICATIONS OF THE FINDINGS. IVF should be used selectively based on judgements on gain compared to continuing expectant management for a given couple. Our results can be used by clinicians to counsel couples with unexplained subfertility, to inform their expectations and facilitate evidence-based, shared decision making.
Do specific ultrasonography features identified at the time of early pregnancy loss predict fetal chromosomal abnormality? – A systematic review and m
Chromosomal abnormality was more likely to occur in embryonic EPL and enlarged YS. On the other hand, short CRL, small GS, symmetrical arrested growth embryo, or gestational sac with only a YS, were not associated with an increased risk of fetal chromosomal abnormality. Ultrasonography features at the time of diagnosis of EPL have limited predictive value of fetal chromosomal abnormality.
Cytological and molecular aspects of the ageing sperm
The role of obesity suggests that conditions related to lifestyle factors may further worsen age-related sperm parameter impairment. Increased SDF and altered protamine expression suggest the genomic fragility of sperm in advanced age. Changes in the miRNA expression pattern with age could contribute to the identification of a characteristic molecular signature of the ageing process, a potential new biomarker for male reproductive function during
Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility [update]
What are the conclusions? Infertility has been found to be an important risk factor for ovarian cancer. However, the association between infertility drugs and ovarian cancer needs to be addressed with consideration of other factors such as age, body mass index, parity, genetic factors (i.e. family history for ovarian cancer), and aetiology of the infertility, along with longer followup times.
Required amount of rFSH, HP-hMG and HP-FSH to reach a live birth: a systematic review and meta-analysis
WIDER IMPLICATIONS OF THE FINDINGS. The differences in the required amount to reach a live birth between rFSH, HP-hMG and HP-FSH appear to be small. Decision-making should be based on convenience, availability, actual costs and patient preferences.
Sperm Morphology: History, Challenges, and Impact on Natural and Assisted Fertility
Summary: Our understanding of the impact of sperm morphology on reproductive outcomes continues to evolve and seems to play less of a role than initially thought.
Ocular Malformations or Poor Visual Acuity in Children Born After In Vitro Fertilization in Sweden [2010 report]
Conclusions. Although there is an increased risk for visual impairment among children born after IVF, the individual risk is small and may be secondary to parental characteristics. No increased risk for eye malformations was found.
In vitro fertilisation was associated with refractive errors when children reached the age of 11
Abstract. The primary formation of the eye in the human embryo takes place between weeks three and 10, when the eye expresses oestradiol and progesterone receptors in multiple ocular structures. After in vitro fertilisation with controlled ovarian hyperstimulation, serum progesterone and oestradiol concentrations are higher than in natural pregnancies up to week six of embryonic development (2). This could imply that these offspring are vulnerabl
High Court rules sperm donor is daughter's legal father, stopping her moving overseas with mother
A man who donated his sperm to a friend with the belief he could play a role in the child's life has won a High Court fight sparked by the mother's decision to move to New Zealand with their biological child.
Does ICSI in first cycle normospermic couples have a lower chance of pregnancy.
Summary
It appears that answer maybe yes.
Comment
This is a retrospective analysis from an Australian clinic of all first, non-donor cycles over a six year period where the male semen profile was within the WHO normal range and where more then 4 oocytes were collected and asked the question - what was the outcome in those cycles that were referred to either IVF or to ICSI? There appeared from the paper there were no other male factors tests applied such as DNA fragmentation applied apart for ASAB. The data was presented as per egg collection (author confirmation) and clearly showed that couples who were referred to IVF rather than ICSI had a statistically higher chance of a live birth. There may have been about another 1 pregnancy in 20 ICSI couples if they had been referred to IVF (maybe).|Even within this ‘normo-spermic’ group of males, the pregnant subpopulation had a better semen profile than the non-pregnant group. They also had less FSH injected and lower doses. There was no data provided on the incidence of failed or poor fertilisation or freeze-all cycles but the fertilisation rates was lower after ICSI than IVF (62% x 67%). There was better embryology in the IVF group given the higher embryo freeze rate.|The authors looked at the data between pregnant and non-pregnant couples and summarised that a range of both male and female factors were better in the pregnant group but multivariate analysis that ranked the importance of these variables identified age, FSH dose, embryology (day of transfer and embryos cryostored) and insemination but not the associated semen profile parameters as predictive. As the authors pointed out, it is almost like the clinicians who made the decision on IVF or ICSI, looked that the semen profile and judged the ICSI group to be marginal in quality although they were within the WHO normal range.|There is no doubt that ICSI is an invasive process where placing a whole sperm inside the oocyte may well start life in an unnatural way. The issues of injection of all oocytes at the same time rather than when the oocyte is ready together with the technical and selection skills of the embryologists all scream - STOP. The reason why ICSI is still over-referred is quite simply a desire of the clinician and the couples to a avoid failed fertilisation and to appear to try to get the most embryos. They may use this paper to encourage couples to consider an IVF rather than an ICSI insemination if they feel strongly about it.|There was one other aspect of this paper that may be worth mentioning. Semen analysis is a single estimate of a male`s fertility but semen quality may be effected by other aspects such as environmental exposures. Repeated semen test may identify such concerns that a single test may not. Maybe a different future procedure could provide a better predictive tool for clinicians rathe than semen analysis. Further, the WHO range is about natural distributions and not about IVF success. Applying WHO normal values as a predictive tool is somewhat dumb and inappropriate. Maybe there needs to be a different set of `normal` ranges (read higher) for IVF that will allow clinicians a more comfortable tool for making an IVF/ICSI decision.|
IVF Training - Questions relating to mailout links -
Open Challenge and complete Questions
Question
Type
Options
The fertilisation rate of IVF and ICSI cycles was
1
4
The clinical pregnancy rate of IVF and ICSI cycles was
1
4
The live brith Rate Of IVF And ICSI Cycles Was
1
5
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
New Developments at FertAid during
May, 2024 and May, 2024
No News
FertAid Functions.
EQA
A range of online Quality Assurance Modules
IVFDaily
New Articles in Press and Interesting, relevant News Items, Business News and other mail
IVFCPD
New education modules
Logbooks
Free Online logbook for IVFLaboratory and Nursing Staff
KPI Benchmarking
New to FertAid. This modules allows ANONYMOUS monthly KPI data entry, management of warning and action limits and anonymous comparisons with country and defined KPI sub-groups
Business
Unlike other mailgroups, IVFDaily will distibute recent business news or developments of interest to IVF staff
to mark the link in your file.
